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Lotte van Dammen, Vincent Wekker, Anne M. van Oers, Meike A. Q. Mutsaerts, Rebecca C. Painter, Aeilko H. Zwinderman, Henk Groen, Cornelieke van de Beek, Anneke C. Muller Kobold, Walter K. H. Kuchenbecker, Ron van Golde, Gerrit J. E. Oosterhuis, Niels E. A. Vogel, Ben Willem J. Mol, Tessa J. Roseboom, Annemieke Hoek, on behalf of the LIFEstyle study group
Effect of a lifestyle intervention in obese infertile women on cardiometabolic health and quality of life: A randomized controlled trial
www.plosone.org
www.plosone.org
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(22)Tj
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(22,)Tj
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1.4683 0 Td
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(Helsinki)Tj
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1.7347 0 Td
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1.4683 0 Td
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3.3619 0 Td
(ethics)Tj
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(Groningen)Tj
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(\(UMCG\))Tj
3.9061 0 Td
(\(METc)Tj
3.0558 0 Td
(code:)Tj
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(2008/284\),)Tj
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(hospitals)Tj
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0.7994 0 Td
(22\).)Tj
1.7348 0 Td
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1.4003 0 Td
(included)Tj
3.7134 0 Td
(participants)Tj
4.9549 0 Td
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1.9956 0 Td
(written)Tj
3.1124 0 Td
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3.5546 0 Td
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1.8368 0 Td
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1.0374 0 Td
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1.4684 0 Td
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5.1193 0 Td
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2.1487 0 Td
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3.4809 0 Td
(\(NTR)Tj
2.5285 0 Td
(1530\))Tj
2.4661 0 Td
(and)Tj
1.7291 0 Td
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0.83 0.64 0.02 0 k
(22)Tj
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(,)Tj
0.83 0.64 0.02 0 k
1.7404 0 Td
(23)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 409.7196 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
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ET
Q
q
1 j
1 J
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10 0 0 10 200.0125 392.7118 cm
BT
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1 TL
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3.4242 0 Td
(women)Tj
3.2031 0 Td
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(18)Tj
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(39)Tj
1.1679 0 Td
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2.4888 0 Td
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2.0012 0 Td
(a)Tj
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0.9865 0 Td
(29)Tj
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ET
Q
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0 w
7.4999 0 0 6.6659 487.6157 397.1338 cm
BT
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1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
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10 0 0 10 493.3984 392.7118 cm
BT
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(24)Tj
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4.4107 0 Td
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3.2315 0 Td
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5.5331 0 Td
(endocrinopathy,)Tj
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4.6318 0 Td
(hypertension,)Tj
5.6919 0 Td
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1.0998 0 Td
(women)Tj
3.2032 0 Td
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1.9955 0 Td
(a)Tj
0.652 0 Td
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0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 313.3417 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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ET
Q
q
1 j
1 J
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10 0 0 10 200.0125 296.3338 cm
BT
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1 TL
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4.1329 0 Td
(or)Tj
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(direct)Tj
2.5285 0 Td
(infertility)Tj
3.9515 0 Td
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4.3597 0 Td
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3.8721 0 Td
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6.1624 0 Td
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4.1896 0 Td
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1.0262 0 Td
(trial)Tj
1.8368 0 Td
(center)Tj
-34.401 -1.2983 Td
(and)Tj
1.7291 0 Td
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4.0195 0 Td
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1.4683 0 Td
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4.2236 0 Td
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3.4356 0 Td
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2.948 0 Td
(in)Tj
1.0375 0 Td
(Amsterdam)Tj
4.9606 0 Td
(with)Tj
1.9956 0 Td
(an)Tj
-35.4385 -1.3039 Td
(online)Tj
2.7609 0 Td
(program.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 230.0031 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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3.7181 0 Td
(intervention)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 212.9952 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
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1.7801 0 Td
(goal)Tj
1.8709 0 Td
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1.0147 0 Td
(the)Tj
1.4741 0 Td
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3.2258 0 Td
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1.7008 0 Td
(a)Tj
0.6519 0 Td
(510%)Tj
2.9254 0 Td
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2.8856 0 Td
(loss)Tj
1.6951 0 Td
(or)Tj
1.0942 0 Td
(a)Tj
0.6576 0 Td
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0 Tc
2.0296 0 Td
(<)Tj
/F8 1 Tf
-0.004 Tc
0.9921 0 Td
(29)Tj
1.1736 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 524.5795 217.4173 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 530.3622 212.9952 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
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(within)Tj
2.8119 0 Td
(six)Tj
-35.8466 -1.2982 Td
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3.5036 0 Td
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1.7858 0 Td
(dietary)Tj
2.9934 0 Td
(therapy,)Tj
3.4752 0 Td
(using)Tj
2.3868 0 Td
(an)Tj
1.2075 0 Td
(online)Tj
2.761 0 Td
(diary,)Tj
2.5001 0 Td
(aimed)Tj
2.6872 0 Td
(at)Tj
0.9525 0 Td
(caloric)Tj
2.897 0 Td
(reduction)Tj
4.1102 0 Td
(of)Tj
1.0148 0 Td
(600)Tj
1.6496 0 Td
(kcal,)Tj
-33.9247 -1.3039 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6519 0 Td
(minimum)Tj
4.2917 0 Td
(intake)Tj
2.6872 0 Td
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1.0148 0 Td
(1200)Tj
2.126 0 Td
(kcal/day)Tj
3.5659 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
2.075 0 Td
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5.0003 0 Td
(were)Tj
2.1203 0 Td
(advised)Tj
3.2144 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(physically)Tj
4.1555 0 Td
(active)Tj
-35.0756 -1.2983 Td
(on)Tj
1.2756 0 Td
(moderate-intensity)Tj
7.8406 0 Td
(level)Tj
2.0125 0 Td
(for)Tj
1.389 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9843 0 Td
(two)Tj
1.7064 0 Td
(or)Tj
1.0999 0 Td
(three)Tj
2.262 0 Td
(times)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(week.)Tj
2.4718 0 Td
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2.3584 0 Td
(physical)Tj
3.4526 0 Td
(activity)Tj
3.118 0 Td
(was)Tj
-34.9679 -1.2983 Td
(stimulated)Tj
4.422 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(pedometer,)Tj
4.7565 0 Td
(aimed)Tj
2.6929 0 Td
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0.9524 0 Td
(10.000)Tj
2.8233 0 Td
(steps)Tj
2.1827 0 Td
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1.5307 0 Td
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1.8651 0 Td
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1.7802 0 Td
(individualized)Tj
-29.6729 -1.2982 Td
(behavioral)Tj
4.3937 0 Td
(modification)Tj
5.3744 0 Td
(was)Tj
1.6951 0 Td
(focused)Tj
3.2825 0 Td
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1.2756 0 Td
(creating)Tj
3.4469 0 Td
(awareness)Tj
4.2633 0 Td
(of)Tj
1.0148 0 Td
(lifestyle)Tj
3.2258 0 Td
(predisposing)Tj
5.3574 0 Td
(to)Tj
1.0261 0 Td
(obesity.)Tj
-34.3556 -1.3039 Td
(The)Tj
1.7801 0 Td
(lifestyle)Tj
3.2315 0 Td
(intervention)Tj
5.176 0 Td
(was)Tj
1.6952 0 Td
(in)Tj
1.0374 0 Td
(concordance)Tj
5.3575 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(recommendations)Tj
7.5004 0 Td
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1.0148 0 Td
(the)Tj
1.4683 0 Td
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3.6906 0 Td
(Insti-)Tj
-35.4214 -1.2983 Td
(tute)Tj
1.7688 0 Td
(of)Tj
1.0148 0 Td
(Health)Tj
2.914 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
-4.5014 -1.2983 Td
(The)Tj
1.7858 0 Td
(lifestyle)Tj
3.2258 0 Td
(intervention)Tj
5.1761 0 Td
(consisted)Tj
3.9401 0 Td
(of)Tj
1.0148 0 Td
(face-to-face)Tj
4.8642 0 Td
(sessions)Tj
3.4072 0 Td
(of)Tj
1.0148 0 Td
(approximately)Tj
5.9754 0 Td
(30)Tj
1.1736 0 Td
(minutes)Tj
3.4638 0 Td
(at)Tj
-36.2378 -1.3039 Td
(the)Tj
1.4683 0 Td
(outpatient)Tj
4.3427 0 Td
(clinics,)Tj
2.982 0 Td
(four)Tj
1.9106 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(three)Tj
2.262 0 Td
(months)Tj
3.2825 0 Td
(and)Tj
1.7291 0 Td
(two)Tj
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