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Over this period, 326 wo\ men entered the )Tj T* (perimenopausal stage while 134 remained in the premenopausal stage. The \ Center for )Tj T* (Epidemiological Studies Depression Scale was used to assess new onset de\ pression; the Life )Tj T* (Experience Survey was administered to evaluate negative life events over\ the study time course.)Tj 0 -2.662 TD (Women who entered the perimenopausal phase were twice as likely to devel\ op a depressive )Tj 0 -1.2 TD (syndrome as women who remained premenopausal. Women who reported vasomot\ or symptoms )Tj T* (such as hot flashes were somewhat more likely to develop depressive symp\ toms. Use of hormone )Tj T* (therapy to ease the symptomatic transition into menopause did not seem t\ o impact the rate of )Tj T* (depressive symptom onset. Women with a history of significant negative l\ ife events were more prone )Tj T* (to developing depressive symptoms compared with women who remained preme\ nopausal.)Tj /TT1 1 Tf 0 -2.634 TD (Viewpoint)Tj ET EMC /Artifact <>BDC Q 0 0 0 rg BT /T1_0 1 Tf 9 0 0 9 18 7.17 Tm (http://www.medscape.com/viewarticle/541959_print \(1 of 2\)13.8.2006 17:\ 27:43)Tj ET EMC endstream endobj 43 0 obj<> endobj 44 0 obj<>stream /Artifact <>BDC 0 0 0 rg 0 i BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9 0 0 9 18 780.17 Tm (Depression During the Menopausal Transition)Tj ET EMC /Article <>BDC q 0 18 612 756 re W* n BT /TT0 1 Tf 13 0 0 13 13 742.0224 Tm (This study helps solidify evidence that transition to menopause is assoc\ iated with an increased risk )Tj 0 -1.2 TD (for the development of a depressive syndrome. Previous studies defined m\ enopause merely by age )Tj T* (or with a variety of criteria including hormone levels, presence of meno\ pausal-related symptoms, or )Tj 0 -1.359 TD (history of menstrual cycle irregularity.)Tj 11.05 0 0 11.05 227.552 696.6962 Tm ([1,2])Tj 13 0 0 13 249.0553 693.1602 Tm ( Strengths of the current study include:)Tj /T1_1 1 Tf 6.5 0 0 6.5 41.8235 655.5602 Tm (l)Tj /TT0 1 Tf ( )Tj 13 0 0 13 56 655.5602 Tm (Provision of a more rigorous definition of transition into the menopausa\ l state; )Tj 0 -1.1 TD ( )Tj /T1_1 1 Tf 6.5 0 0 6.5 41.8235 626.9602 Tm (l)Tj /TT0 1 Tf ( )Tj 13 0 0 13 56 626.9602 Tm (Evaluation of women with no previous depression history; and )Tj T* ( )Tj /T1_1 1 Tf 6.5 0 0 6.5 41.8235 598.3602 Tm (l)Tj /TT0 1 Tf ( )Tj 13 0 0 13 56 598.3602 Tm (Assessment of how vasomotor symptoms impact development of depression.)Tj -3.308 -4.354 Td (The milder degree of depressive symptoms in those taking hormone therapy\ compared with those )Tj 0 -1.2 TD (not taking hormone therapy hints at the possibility of a protective effe\ ct from hormone therapy in this )Tj T* (population.)Tj 0 -2.662 TD (Self-reports of symptoms of depression and absence or presence of vasomo\ tor symptoms is a )Tj 0 -1.2 TD (possible study limitation. These subjective assessments may not be as ac\ curate as more objective )Tj T* (means to determine this information.)Tj 0 -2.662 TD (Nonetheless, this well-designed, prospective, longitudinal study enhance\ s our understanding of an )Tj 0 -1.2 TD (area of women's health that, until recently, has been largely ignored.)Tj /TT1 1 Tf 0 -2.662 TD (Abstract \(PubMed\) URL:)Tj ET 0 0 0.4 RG 0.624 w 10 M 0 j 0 J []0 d 163.215 358.088 m 443.547 358.088 l S 0 0 0.4 rg BT /TT0 1 Tf 13 0 0 13 163.215 359.9602 Tm (www.medscape.com/medline/abstract/16585467)Tj 0 0 0 rg /TT1 1 Tf 15 0 0 15 13 322.0552 Tm (References)Tj /TT0 1 Tf 13 0 0 13 37.93 283.3602 Tm (1. )Tj (Bungay GT, Vessey MP, McPherson CK. Study of symptoms of middle life wit\ h special )Tj 1.39 -1.2 Td (reference to the menopause. Br Med J.1980;281:181-183. )Tj -1.39 -1.2 Td (2. )Tj (Hunter M, Battersby R, Whitehead M. Relationships between psychological \ symptoms, )Tj 1.39 -1.2 Td (somatic complaints and menopausal status. Maturitas. 1986;8:217-228.)Tj -3.231 -2.036 Td ( )Tj /TT1 1 Tf -0.077 -2.01 Td (Irving Kuo, MD)Tj /TT0 1 Tf (, Assistant Professor of Psychiatry, University of Arkansas for Medical \ Sciences, )Tj 0 -1.227 TD (Little Rock, Arkansas; Staff Psychiatrist, Central Arkansas Veterans Hea\ lthcare System, Little Rock)Tj 0 -1.1 TD ( )Tj T* (Disclosure: Irving Kuo, MD, has disclosed no relevant financial relation\ ships.)Tj T* ( )Tj ET 0.5 0.5 0.5 rg 13 113.934 586 1 re f 0 0 0 rg BT /TT0 1 Tf 11.172 0 0 11.172 11 95.4895 Tm ( )Tj 0.368 0 Td ( )Tj ET EMC /Artifact <>BDC Q BT /T1_0 1 Tf 9 0 0 9 18 7.17 Tm (http://www.medscape.com/viewarticle/541959_print \(2 of 2\)13.8.2006 17:\ 27:43)Tj ET EMC endstream endobj 45 0 obj(Depression During the Menopausal Transition) endobj 46 0 obj<> endobj 47 0 obj<> endobj 48 0 obj<> endobj 49 0 obj<> endobj 50 0 obj[47 0 R] endobj 51 0 obj(http://www.medscape.com/viewarticle/541959_print) endobj 52 0 obj(ڝxJZ=@) endobj 53 0 obj<> endobj 54 0 obj<> endobj 55 0 obj(~G3폕#Bd) endobj 56 0 obj 1 endobj 57 0 obj<> endobj 58 0 obj<> endobj 59 0 obj<>stream 2006-08-13T17:27:43+02:00 2006-08-13T17:27:29+02:00 2006-08-13T17:27:43+02:00 application/pdf Depression During the Menopausal Transition uuid:e4065e3d-806b-4555-934b-88dff063349b uuid:1d9da830-2a1e-4053-868c-651bcb31e613 Acrobat Web Capture 7.0 endstream endobj xref 0 60 0000000004 00000 f 0000000016 00000 n 0000000144 00000 n 0000000202 00000 n 0000000006 00000 f 0000000377 00000 n 0000000000 00001 f 0000000443 00000 n 0000000487 00000 n 0000000728 00000 n 0000001727 00000 n 0000001816 00000 n 0000001850 00000 n 0000001936 00000 n 0000001987 00000 n 0000002030 00000 n 0000002085 00000 n 0000002140 00000 n 0000002243 00000 n 0000002288 00000 n 0000002337 00000 n 0000002435 00000 n 0000002723 00000 n 0000002767 00000 n 0000002791 00000 n 0000002932 00000 n 0000002977 00000 n 0000003129 00000 n 0000003281 00000 n 0000003448 00000 n 0000003665 00000 n 0000003689 00000 n 0000003868 00000 n 0000003892 00000 n 0000003982 00000 n 0000005155 00000 n 0000005375 00000 n 0000006552 00000 n 0000006778 00000 n 0000007955 00000 n 0000008193 00000 n 0000009373 00000 n 0000009600 00000 n 0000013206 00000 n 0000013272 00000 n 0000016817 00000 n 0000016878 00000 n 0000016914 00000 n 0000016997 00000 n 0000017026 00000 n 0000017127 00000 n 0000017151 00000 n 0000017217 00000 n 0000017251 00000 n 0000017369 00000 n 0000017420 00000 n 0000017454 00000 n 0000017472 00000 n 0000017558 00000 n 0000017681 00000 n trailer <<362E9E0CCC8DD748B79BC7452C1E1659>]>> startxref 21175 %%EOF