ࡱ> lnk`bjbj 4"VVVVVVVj2 2 2 2 > j ^ : P R R R R R R $ h'`v V v VV X X X V V P X P X X VVX R zQå2 X  < 0 X 2 X X Vl X v v N jjjddjjjjjjVVVVVV  HYPERLINK "http://www.gynecologicalendocrinology.org/sito_gynendo/index.htm"  INCLUDEPICTURE "http://www.gynecologicalendocrinology.org/sito_gynendo/pagine_interne_n1/imgs/top_the_editorial.gif" \* MERGEFORMATINET  CONTRACEPTION: THE NEED OF A NEW CONTRACEPTIVE REVOLUTION  INCLUDEPICTURE "http://www.gynecologicalendocrinology.org/sito_gynendo/imgs/P_Bouchard.jpg" \* MERGEFORMATINET  Philippe Bouchard Service d'Endocrinologie, Hopital Saint Antoine, 75012 Paris, France Since the approval of the first contraceptive pill on May 11 1960, contraceptive methods have been flourishing, although some drawbacks have been identified such as the risk of thromboembolic disease related to the use of Ethinyl Estradiol (EE) as well as the potential cardiovascular risks in women who smoke after 35. However, the needs remain enormous, although women can now choose between a variety of combined OCs, containing less and less EE, progestin only pills, implants, vaginal rings, patches, and IUD/IUS. The first reason is the population growth, especially in developing countries, where many young women at reproductive age live. According to the UN Division of Population, the World population is growing, to reach eventually 9.2 billions (2.3-36.4) in 2075 vs. 6.4 presently and stabilize thereafter (1). These previsions are certainly largely speculative because they depend on the future of the fertility rate which may decrease significantly in the future (the so called second demographic transition), particularly if the trend for later pregnancies is confirmed. However, the need for further research is clear since, although fertility control is the key of economic progress, a very large number of women do not have access to contraception: Presently 60 % of women at age of reproduction are using a contraceptive method, 20% in Africa, 70 % in Europe, 69% in China, 66% in Latin America. Another important point to consider is that the need for new methods is also important in the western world where the rate of unwanted pregnancy remains too high, to reach in some countries, one third of pregnancies. This explains the high number of abortions which does not decrease (e.g. 220000 every year in France) despite the availability of multiple methods of contraception, and the free access of these methods, sometimes without prescription, in France. The reasons for this too high rate of unwanted pregnancies are multiple and involve poor education on contraceptive methods, and the lack of compliance, eventually because of side effects, and because of the need of daily compliance. The search for new methods is therefore mandatory, in order to design techniques that are easy to use, long acting, and devoid of adverse events. Finally Pharma industry seems to have somehow lost interest in this area where a lot of methods already exist and where the return on investment requires aggressive marketing and the struggle for a reasonable price in front of national policies of reimbursements. In the last years new pills have been approved, although not very different from the previous ones. We therefore need better availability of contraceptive devices, at the lowest possible price, where it is needed, and at the same time, renewal of techniques in order to improve the choice offered to women. If more research is needed, the new avenues remain questionable: male contraception although progressing with the excellent results obtained with progestin implants associated with testosterone substitution, still remains a very low priority for the Pharma Industry. All the excellent ideas formulated by conferences since 1970 have remained theoretical, few concepts, if any, have been able to reach clinical use. Last but not least the recent meeting organized by the respected Institute of Medicine (2004), has provided a blueprint for research involving the use of new Genomics and Proteomics technology, however their conclusion still looks very much like science fiction. This editorial praises for new research involving basic and clinical studies, investigating the crucial genes and proteins involved in ovarian physiology and spermatogenic function. We certainly hope that new Genomic studies using SNPs analysis will help us in this endeavour. [1] UN, Population division - World population to 2300, oct. 2004, (http://www.un.org/esa/population/publications/longrange2/WorldPop2300final.pdf)  International Society of Gynecological Endocrinology- n. 11 July 2007  OPQ   LMNP]^hivwƽƵƵƧơƛƛƛƛơʗh hPp0J hPp0J hPp0Jj2;hPpUjhPpUhPp0J5\hPphPpCJaJhPp5B*\phjhPp5B*U\ph hPp5\jhPp5U\$ + t,JL$If $$Ifa$gdPp $$Ifa$gdPp $$Ifa$$If:kd:$$IfT(#(#(#634aT $$Ifa$LM~:kd}$$IfT(#(#634aT $$Ifa$:kd}$$IfT(#(#634aT21h:pPp. 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